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KMID : 0857020060210010260
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Kosin Medical Journal
2006 Volume.21 No. 1 p.260 ~ p.269
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The Expression of Vascular Endothelial Growth Factor, Microvessel Density and Matrix Metalloproteinase-2, -9 in Endometrial Cancer
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Kim Hyun
Kim Wan-Gyu
Huh Bang
Kim Weon
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Abstract
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Background : Tumor angiogenesis and degradation of subepithelial basement membrane and extracellular matrix are essential steps for tumor growth, invasion, progression and metastasis. Vascular endothelial growth factor (VEGF) is an important regulator of tumor angiogenetic process and strong VEGF expression is associated with increased microvessel density and poor outcome of endometrial cancer patient. Matrix metalloproteinases(MMPs) are a family of enzymes appear to play a key role in degradations of basement membrane and extracellular matrix, and is responsible for cancer invasion, progression and metastasis and be associeated with poor outcome of patient. The aim of this study is to examine the expression of VEGF, MVD and MMPs in endometrial cancer and then to examine the correlation between these factors with prognostic parameters of endometrial cancer.
Method : We studied clinicopathologic characteristics of 62 endometrial cancer patients who were diagnosed and operated at Kosin university, Gospel Hospital from January 1995 to December 2003, and investigated the expression of VEGF, microvessel density. MMP-2, and MMP-9 by using immunohistochemistry, then compared these data with the established prognostic parameters of endometrial cancer.
Results : There was no statistical correlation between VEGF and clinicopathologic parameters. The MVD also showed no statistical correlation with clinicopathologic parameters but p-value was close to 0.05 in CA-125 level (p=0.051). In MMP-2,-9, there was no statistical correlation between VEGF and MVD. There was also no statistical correlation between VEGF, MVD and MMP-2,-9.
Conclusion : In this study, the expression of VEGF and MMP-2,-9 and MVD were not correlated with prognostic parameters such as stage, histology, grade, myometrial invasion depth, lymph node metastasis and preop CA-125 level in this study and there was no correlation between VEGF, MVD and MMP-2,-9. It was regarded that there need further study with more cases and based on survival in the future.
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KEYWORD
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Vascular endothelial growth ractor(VEGF), Microvessel density (MVD), Matrix metalloproteinase -2, -9
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